Introducing MyOva Preconception

MyOva Fertilityplus is a natural food supplement for adults aged 18 years and over, who have PCOS and are trying to conceive.

It is a natural preconception supplement containing essential micronutrients to help support reproductive health for pregnancy. It contains additional nutrients that have been found to support ovulation and metabolic health specifically for people living with PCOS (as outlined in table 4).

MyOva Fertilityplus presents in a convenient, easy to swallow tablet format which can easily be crushed and taken with food. The optimum dose is achieved by taking two tablets in the morning and two in the evening, daily with water or food. Patients should be advised to discuss with their GP first if they are taking regular medication or are lactating. MyOva Fertilityplus should not be taken as a substitute for a healthy and balanced diet.

Table 4: MyOva Fertilityplus ingredients and their role in PCOS

Ingredient*

Role

Alpha-Lipoic Acid (ALA) (600mg)

There is a possible beneficial effect on oocyte and embryo quality using a combination of myo-inositol, ALA, and folate supplementation for people with PCOS and undergoing In Vitro Fertilisation (IVF) (35). In a small patient cohort (n = 40), the combination of myo-inositol and ALA for six months decreased BMI, waist-hip ratio, hirsutism score, AMH, ovarian volume, antral follicle count, and increased the number of menstrual cycles (36). Another small study (n=16) examined the effects of a combination of MI and ALA over 24-months. A decrease in BMI was noted at six months and menstruation cycle length continued to normalise at 24 months (37). Further RCTs are needed to assess its clinical impact on IVF.

Folate (400μg)

At least 400μg of folic acid is recommended daily before pregnancy and throughout the first 12 weeks to prevent neural tube defects (38). In an observational study, 3,602 infertile women used MI and folic acid between 2- 3 months in a dosage of  4000mg myoinositol with 400 μg folic acid per day. In a subgroup of 32 patients, hormonal values for testosterone, free testosterone, and progesterone were analysed before and after 12 weeks. During this time 70% of these women had restored ovulation, and 545 pregnancies were obtained. Pregnancy rate was 15.1% in the MIl and folic acid users (39).

N-acetyl cysteine (600mg)

N‐acetyl cysteine has been found to improve the metabolic profile in people with PCOS (40, 41).

Coenzyme Q10 (10mg)

Coenzyme Q10 appears to be a promising treatment to stimulate and maintain ovarian health in people with PCOS who are trying to conceive. Further studies are needed to assess this association (42).

*amount per four tablets

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