1. Teede H, et al. (2018). International evidence-based guideline for the assessment and management of polycystic ovary syndrome. National Health and Medical Research Council (NHMRC).[Internet]. Available online:

2. Sawant S, Bhide P (2019). Fertility Treatment Options for Women With Polycystic Ovary Syndrome. Clinical Medicine Insights Reproductive Health. [Internet]. Available from: /pmc/articles/PMC6935873/

3. Diamanti-Kandarakis E, Dunaif A (2012). Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications. Endocrine reviews;33(6):981–1030. [Internet]. Available from:

4. The British Medical Journal (BMJ). Polycystic ovary syndrome - History and exam | BMJ Best Practice. 2021. [Internet]. Available from:

5. The Rotterdam ESHRE/ASRMsponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and longterm health risks related to polycystic ovary syndrome (PCOS). Human Reproduction. 2004. [Internet].Available from:

6. Palomba S, et al. (2015). Pregnancy complications in women with polycystic ovary syndrome. Human Reproduction Update;21(5):575-92. [Internet]. Available from: doi: 10.1093/humupd/dmv029.

7. National Institute for Health and Care Excellence (NICE). Scenario: Management - adults | Management | Polycystic ovary syndrome. 2018. [Internet]. Available from:

8. Kriedt K, Alchami A, Davies M (2019). PCOS: diagnosis and management of related infertility. Obstetrics, Gynaecology & Reproductive Medicine;29(1):1–5.  [Internet]. Available from:

9. Ayala C, et al. (1999). Serum testosterone levels and reference ranges in reproductive-age women. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. [Internet]. Available from:

10. GloucestershireHospitals NHS Trust. Sex Hormone Binding Globulin (SHBG). 2021. [Internet]. Available from:

11. National Institute for Health and Care Excellence (NICE). Recommendations  | Weight management: lifestyle services for overweight or obese adults | Guidance | NICE. 2014. [Internet]. Available from:

12.Barr S, et al. (2013). An isocaloric low glycemic index diet improves insulin sensitivity in women with polycystic ovary syndrome. Journal of the Academy of Nutrition and Dietetics;113(11):1523–31. [Internet]. Available from:

13. Zhang X, et al. (2019). The Effect of Low Carbohydrate Diet on Polycystic Ovary Syndrome: A Meta-Analysis of Randomized Controlled Trials. International Journal of Endocrinology. 26;2019:4386401. [Internet]. Available from: doi: 10.1155/2019/4386401.

14. Barrea L,  et al. (2019). Adherence to the Mediterranean Diet, Dietary Patterns and Body Composition in Women with Polycystic Ovary Syndrome (PCOS). Nutrients;11(10). [Internet]. Available from:

15. Brutocao C, et al. (2018). Psychiatric disorders in women with polycystic ovary syndrome: a systematic review and meta-analysis. Endocrine.[Internet]. Available from:

16. Nordio M, Basciani S, Camajani E (2019). The 40:1 myo-inositol/D-chiro-inositol plasma ratio is able to restore ovulation in PCOS patients: comparison with other ratios. European Review for Medical and Pharmacological Sciences;23(12):5512-5521.[Internet]. Available from: doi: 10.26355/eurrev_201906_18223.

17. Unfer V, et al. (2017). Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials. Endocrine Connections; 6(8):647–58[Internet]. Available from:

18. Brown J, et al. (2016). Dietary supplementation with myoinositol in women during pregnancy for treating gestational diabetes. Cochrane Database of Systematic Reviews [Internet].Sep 7 [cited 2021 Oct 19];2016(9). Available from:

19. Merviel P, et al.  (2021). Impact of myo-inositol treatment in women with polycystic ovary syndrome in assisted reproductive technologies. Reproductive Health;18(1):1–8 18. [Internet]. Available from:

20. Facchinetti F, et al. (2019). Short-term effects of metformin and myo-inositol in women with polycystic ovarian syndrome (PCOS): a meta-analysis of randomized clinical trials. Gynecological endocrinology.[Internet]. Available from: https://pubmed.

21. Gerli S, et al. (2007). Randomized, double blind placebo-controlled trial: effects of myo-inositol on ovarian function and metabolic factors in women with PCOS. European Review forMedicalandPharmacologicalSciences;11(5):347-54. [Internet]. Available from: PMID: 18074942.

22. Formuso C, Stracquadanio M, Ciotta L (2015). Myo-inositol vs. D-chiro-inositol in PCOS treatment. Minerva Obstetrics and Gynaecology;67(4):321-5. [Internet]. Available from: PMID: 25670222.

23. u-Allah I, et al. (2020). Myoinositol In Restoring Spontaneous Ovarian Activity in Patients with Polycystic Ovarian Syndrome (PCOS). [Internet]. Available from: doi: 10.51273/esc20.2516310.

24. Pundir J, et al. (2018). Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta-analysis of randomised trials. An International Journal of Obstetrics and Gynaecology;125: 299– 308.

25. Akbari Sene A,  et al.  (2019). The myo-inositol effect on the oocyte quality and fertilization rate among women with polycystic ovary syndrome undergoing assisted reproductive technology cycles: a randomized clinical trial. Archives of Gynaecology and Obstetrics;299(6):1701-1707. [Internet]. Available from: doi: 10.1007/s00404-019-05111-1

26. Mendoza N, et al. (2017). Inositol supplementation in women with polycystic ovary syndrome undergoing intracytoplasmic sperm injection: a systematic review and meta-analysis of randomized controlled trials. Reproductive biomedicine online. [Internet]. Available from:

27. Crawford T,  et al. (2015). Antenatal dietary supplementation with myo-inositol in women during pregnancy for preventing gestational diabetes. Cochrane Database of Systematic Reviews. [Internet]. Available from:

28. Minozzi M, D'Andrea G, Unfer V (2008). Treatment of hirsutism with myo-inositol: a prospective clinical study. Reproductive biomedicine;17(4):579–82.  [Internet]. Available from:

29. Zacche M, et al. (2009).  Efficacy of myoinositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome. Gynecol Endocrinol; 25: 508–13.

30. Pezza M, Carlomagno V (2017) Inositol in women suffering from acne and PCOS: a randomized study. Glob Dermatol 4: doi: 10.15761/GOD.1000203

31. Fruzzetti F,  et al. (2017). Comparison of two insulin sensitizers, metformin and myo-inositol, in women with polycystic ovary syndrome (PCOS). Gynecological Endocrinology;2;33(1):39–42. 

32. Asemi Z, Karamali M, Esmaillzadeh A (2014). Metabolic response to folate supplementation in overweight women with polycystic ovary syndrome: A randomized double-blind placebo-controlled clinical trial. Molecular Nutrition and Food Research;58(7):1465–73.

33. Cochrane Central Register of Controlled Trials. Chromium and Insulin Resistance. 2018. [Internet]. Available from:

34. Fazelian S, et al. (2017). Chromium supplementation and polycystic ovary syndrome: A systematic review and meta-analysis. Journal of Trace Elements in Medicine and Biology;42:92-96.[Internet]. Available from: doi: 10.1016/j.jtemb.2017.04.008.

35. Canosa S, et al. (2020). Effect of a combination of myo-inositol, alpha-lipoic acid, and folic acid on oocyte morphology and embryo morphokinetics in non-PCOS overweight/obese patients undergoing IVF: A pilot, prospective, randomized study. Journal of Clinical Medicine;1;9(9):1–13.

36. De Cicco S, et al. (2017). Myoinositol combined with alpha-lipoic acid may improve the clinical and endocrine features of polycystic ovary syndrome through an insulin-independent action. Gynecology and. Endocrinology;.33:698–701.[Internet]. Available from: doi: 10.1080/09513590.2017.1313972

37. Fruzzetti F, et al, (2020).. Long-term treatment with α-lipoic acid and myo-inositol positively affects clinical and metabolic features of polycystic ovary syndrome. Gynecology and Endocrinology;36:152–155. [Internet]. Available from: doi: 10.1080/09513590.2019.1640673

38. National Institute for Health and Care Excellence (NICE). Recommendations  | Maternal and child nutrition PH11. (2008). [Internet]. Available from:

39. Regidor P, Schindler A (2016) . Myoinositol as a Safe and Alternative Approach in the Treatment of Infertile PCOS Women: A German Observational Study. International Journal of Endocrinology. Available from: doi: 10.1155/2016/9537632.

40. Lak T, et al. (2017). N-acetyl cysteine in ovulation induction of PCOS women underwent intrauterine insemination: an RCT. International journal of reproductive biomedicine. [Internet]. Available from:

41. Gupta V,  et al. (2017). A study of N-acetyl cysteine, metformin and vitamin D3 with calcium on clinical and metabolic profile in PCOS. International journal of reproduction, contraception, obstetrics and gynecology.[Internet]. Available from:

42. Sharma D sen (2017). Co-enzyme Q10-A mitochondrial antioxidant -a new hope for success in infertility in clomiphene-citrate-resistant polycystic ovary syndrome. An International Journal of Obstetrics and Gynaecology. [Internet]. Available from: